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PEER REVIEWED PUBLISHED RESEARCH – The National Library of Medicine’s Website – Search Results “Oxidative Stress”

To search the connection of oxidative stress to any health concern, simply go to and type in “Oxidative Stress *Health Issue*” (ie: Oxidative Stress Cancer, Oxidative Stress Diabetes) etc. – Search Results “Protandim” – Search Results “NRF2”

Protandim NRF is NSF certified (quality standards) & BSCG (Banned substances – Olympic, NCAA, NFL) approved. Click on the logos below to learn more!


2006: The induction of human superoxide dismutase and catalase in vivo: A fundamentally new approach to antioxidant therapy, Free Radical Biology & Medicine 40 (2006) 341-347

2007: Proinflammatory and Oxidative Stress Markers in Patients with Periodontal Disease, Mediators of Inflammation, Vol. 2007, Article ID 45794

2009: Synergistic induction of heme oxygenase-l by the components of the antioxidant supplement Protandim, Free Radical Biology & Medicine 46 (2009) 430-440

2009: Protandim, a Fundamentally New Antioxidant Approach in Chemoprevention Using Mouse Two-Stage Skin Carcinogenesis as a Model, PLoS ONE 4(4): e5284. doi:10.1371/journal.pone.0005284

2009: Chronic Pulmonary Artery Pressure Elevation Is Insufficient to Explain Right Heart Failure, Circulation (Journal of the American Heart Association), published online Nov. 2, 2009

2010: Nrf2, a Guardian of Healthspan and Gatekeeper of Species Longevity, Integrative and Comparative Biology (May 6, 2010) pp. 1-15

2010: The Dietary Supplement Protandim Decreases Plasma Osteopontin and Improves Markers of Oxidative Stress in Muscular Dystrophy Mdx Mice, Journal of Dietary Supplements, Vol. 7(2), 2010

2010: The Chemopreventive Effects of Protandim: Modulation of p53 Mitochondrial Translocation and Apoptosis during Skin Carcinogenesis, PLoS ONE 5(7): e11902. doi:10.1371/journal.pone.0011902

2010: Protandim attenuates intimal hyperplasia in human saphenous veins cultures ex vivi a catalase-dependent pathway, Free Radical Biology & Medicine (2010)

2011: The Role of Manganese Superoxide Dismutase in Skin Cancer, Enzyme Research, Vol. 2011, Article ID 409295

2011: Nrf2 activators: a novel strategy to promote oligodendrocyte survival in multiple sclerosis?, 5th Joint triennial congress of the European and Americas Committees for Treatment and Research in Multiple Sclerosis, Amsterdam, the Netherlands. 19.10.2011-11.10.2011

2011: Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation, Molecular Aspects of Medicine 32 (2011) 234-246

2012: Phytochemical Activation of Nrf2 Protects Human Coronary Artery Endothelial Cells against an Oxidative Challenge, Oxidative Medicine and Cellular Longevity, Vol. 2012, Article ID 132931

2013: The Role of Nrf2 in the Attenuation of Cardiovascular Disease, Exercise and Sport Sciences Reviews (peer-reviewed article)

2015: The role of transcription factor Nrf2 in osteoarthritis, Universite de Montreal (peer-reviewed thesis paper) (2015)

2015: Nrf2, a master regulator of detoxification and also antioxidant, anti- inflammatory and other cytoprotective mechanisms, is raised by health promoting factors, Acta Physiologica Sinica, February 25, 2015, 67(1): 1-18

2016: Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer, Aging Cell (2016) pp1–13

2016 Elucidating the Role of Protandim and 6-Gingerol in Protection Against Osteoarthritis.  J Cell Biochem. 2016 Jul 27. University of Montreal.

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