Product Knowledge



You can find these and many other helpful tools in your back office under the tab “Communications” and clicking on the dropdown menu item called “Library”

PEER REVIEWED PUBLISHED RESEARCH – The National Library of Medicine’s Website – Search Results “Oxidative Stress”

To search the connection of oxidative stress to any health concern, simply go to and type in “Oxidative Stress *Health Issue*” (ie: Oxidative Stress Cancer, Oxidative Stress Diabetes) etc. – Search Results “Protandim” – Search Results “NRF2”

Protandim NRF is NSF certified (quality standards) & BSCG (Banned substances – Olympic, NCAA, NFL) approved. Click on the logos below to learn more!


2006: The induction of human superoxide dismutase and catalase in vivo: A fundamentally new approach to antioxidant therapy, Free Radical Biology & Medicine 40 (2006) 341-347

2007: Proinflammatory and Oxidative Stress Markers in Patients with Periodontal Disease, Mediators of Inflammation, Vol. 2007, Article ID 45794

2009: Synergistic induction of heme oxygenase-l by the components of the antioxidant supplement Protandim, Free Radical Biology & Medicine 46 (2009) 430-440

2009: Protandim, a Fundamentally New Antioxidant Approach in Chemoprevention Using Mouse Two-Stage Skin Carcinogenesis as a Model, PLoS ONE 4(4): e5284. doi:10.1371/journal.pone.0005284

2009: Chronic Pulmonary Artery Pressure Elevation Is Insufficient to Explain Right Heart Failure, Circulation (Journal of the American Heart Association), published online Nov. 2, 2009

2010: Nrf2, a Guardian of Healthspan and Gatekeeper of Species Longevity, Integrative and Comparative Biology (May 6, 2010) pp. 1-15

2010: The Dietary Supplement Protandim Decreases Plasma Osteopontin and Improves Markers of Oxidative Stress in Muscular Dystrophy Mdx Mice, Journal of Dietary Supplements, Vol. 7(2), 2010

2010: The Chemopreventive Effects of Protandim: Modulation of p53 Mitochondrial Translocation and Apoptosis during Skin Carcinogenesis, PLoS ONE 5(7): e11902. doi:10.1371/journal.pone.0011902

2010: Protandim attenuates intimal hyperplasia in human saphenous veins cultures ex vivi a catalase-dependent pathway, Free Radical Biology & Medicine (2010)

2011: The Role of Manganese Superoxide Dismutase in Skin Cancer, Enzyme Research, Vol. 2011, Article ID 409295

2011: Nrf2 activators: a novel strategy to promote oligodendrocyte survival in multiple sclerosis?, 5th Joint triennial congress of the European and Americas Committees for Treatment and Research in Multiple Sclerosis, Amsterdam, the Netherlands. 19.10.2011-11.10.2011

2011: Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation, Molecular Aspects of Medicine 32 (2011) 234-246

2012: Phytochemical Activation of Nrf2 Protects Human Coronary Artery Endothelial Cells against an Oxidative Challenge, Oxidative Medicine and Cellular Longevity, Vol. 2012, Article ID 132931

2013: The Role of Nrf2 in the Attenuation of Cardiovascular Disease, Exercise and Sport Sciences Reviews (peer-reviewed article)

2015: The role of transcription factor Nrf2 in osteoarthritis, Universite de Montreal (peer-reviewed thesis paper) (2015)

2015: Nrf2, a master regulator of detoxification and also antioxidant, anti- inflammatory and other cytoprotective mechanisms, is raised by health promoting factors, Acta Physiologica Sinica, February 25, 2015, 67(1): 1-18

2016: Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer, Aging Cell (2016) pp1–13

2016 Elucidating the Role of Protandim and 6-Gingerol in Protection Against Osteoarthritis.  J Cell Biochem. 2016 Jul 27. University of Montreal.

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